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Clinical Trials for Glioma Brain Tumors

What is a glioma?

Gliomas are ‘primary’ brain tumors, which means they are derived from the brain tissue itself. Common subtypes include astrocytoma, oligodendroglioma, glioblastoma, and gliosarcoma. All gliomas are graded based upon World Health Organization (WHO) criteria.

Grades II, III, and IV gliomas are most common in adults. Grade IV gliomas (known as glioblastomas or gliosarcomas) are the most common primary brain cancer in adults. Glioblastoma is a rapidly growing tumor that can occur at any age, but its incidence increases with advanced age. Grades I, II, and III gliomas are less aggressive and often seen in younger populations, yet can still recur and defy conventional therapies. All gliomas cause symptoms through a combination of mass effect on the surrounding brain and direct infiltration of the brain tissue.

Gliomas are a primary focus of the Ivy Brain Tumor Center and a large proportion of our clinical trials portfolio focuses on higher-grade gliomas.

World Health Organization (WHO) Criteria

Grade I
Slow-growing tumor cells; almost normal appearance; least aggressive
Grade II
Relatively slower-growing cells; slightly abnormal appearance; often invade nearby tissue; may recur as a higher-grade tumor
Grade III
Faster-dividing cells; abnormal appearance; infiltrates normal tissue and often recurn as higher-grade tumor
Grade IV
Rapidly-dividing and abnormal cells; contains necrotic areas of nonviable tissue

Brain Tumor Symptoms

Brain tumor symptoms vary widely depending on the type, location, size and growth rate of the tumor. There are no specific symptoms that only occur due to a glioma tumor.

General symptoms of brain tumors include:

  • New onset or change in pattern of headaches
  • Headaches that gradually become more frequent and more severe
  • New onset of seizures
  • Gradual loss of sensation or movement in an arm or a leg
  • Difficulty with balance
  • Difficulty speaking
  • Personality or behavior changes
  • Confusion
  • Unexplained nausea or vomiting
  • Blurred vision, double vision, or loss of peripheral vision
  • Hearing problems

Contact your physician if you are experiencing any of these symptoms.

PHASE 0 CLINICAL TRIALS FOR RECURRENT GLIOMA  PATIENTS

If you have a glioma and undergone MR imaging that shows evidence of tumor recurrence, you may be a candidate for one of our Phase 0 clinical trials. Our Phase 0 studies provide you with information you can use right now to make informed treatment decisions. This knowledge allows you to have a voice in your care and places some control back into your hands.

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Am I Eligible?

View a list of our open trials and receive a free trial screening to determine your eligibility.

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What is a Phase 0 Clinical Trial?

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