What is a glioma Brain tumor?
Gliomas are primary brain tumors, which means they are derived from the brain tissue itself. Common subtypes include astrocytoma, oligodendroglioma, glioblastoma, and gliosarcoma.
All gliomas are graded based upon World Health Organization (WHO) criteria:
Grades II, III, and IV gliomas are most common in adults. Grades I, II, and III gliomas are less aggressive and often seen in younger populations, yet can still recur and defy conventional therapies. All gliomas cause symptoms through a combination of mass effect on the surrounding brain and direct infiltration of the brain tissue.
What is a high-grade glioma brain tumor?
A high-grade glioma or Grade IV gliomas (known as glioblastomas or gliosarcomas) are the most common primary brain cancer in adults. Glioblastoma is a rapidly growing tumor that can occur at any age, but its incidence increases with advanced age.
Gliomas are a primary focus of the Ivy Brain Tumor Center and a large proportion of our clinical trials portfolio focuses on high-grade gliomas.
What is a recurrent glioblastoma brain tumor?
A glioblastoma that appears to have returned after a patient has undergone initial treatment is called a recurrence.
Even after maximal surgical resection, microscopic glioblastoma cells often remain and can grow back over time. To slow their growth, patients are treated with the current standard of care which consists of temozolomide chemotherapy and radiation therapy. However, standard treatment is not curative and most patients experience tumor progression.To monitor for tumor regrowth, patients are scheduled for follow-up visits and routine MRI scans. Regardless of whether you are newly diagnosed or have been informed by a doctor that your tumor has recurred (come back), you may be eligible for an Ivy Phase 0 clinical trial.