Tien Laboratory

Researcher holding a bottle of liquid in the lab


We actively pursue new drug combination clinical trials for brain tumor patients. The newly developed Phase 0 platform combined with precision medicine allows us to understand pharmacodynamic endpoints in the tumor, providing insights for overcoming the brain-blood barrier and drug target inhibition. The newly established Ivy Pharmacodynamics Core is CLIA-certified where our assays and biosamples are validated and carefully monitored to provide trustworthy clinical quality results. Our long-term goal is to understand cellular and molecular mechanisms underlying glioma formation, thereby speeding current drug discovery processes for glioma treatment in patients.

Principal Investigator

Lab Members

YuWei Chang hexagon cutoutRead Bio

YuWei Chang, PhDPostdoctoral Fellow

Chelsea Pennington-Krygier hexagon cutoutRead Bio

Chelsea Pennington-KrygierCLIA Lab Manager, Research Tech

Anita DeSantis hexagon cutoutRead Bio

Anita DeSantisResearch Technician


Research Technician I

We are currently recruiting for a highly motivated and driven research technician, (B.S.) to join our CLIA-certified pharmacodynamics team focusing on cutting edge Phase 0 clinical trials for glioblastoma. Candidates with experience in preclinical studies are desirable. Prior experience in conducting histo-immunochemistry and knowledge of signal transduction pathways is preferred.