Tien Laboratory

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About

We actively pursue new drug combination clinical trials for brain tumor patients. The newly developed Phase 0 platform combined with precision medicine allows us to understand pharmacodynamic endpoints in the tumor, providing insights for overcoming the brain-blood barrier and drug target inhibition. The newly established Ivy Pharmacodynamics Core is CLIA-certified where our assays and biosamples are validated and carefully monitored to provide trustworthy clinical quality results. Our long-term goal is to understand cellular and molecular mechanisms underlying glioma formation, thereby speeding current drug discovery processes for glioma treatment in patients.

Current Research

Some of the ongoing projects are focused on addressing following:

  1. Biomarker and genomic analyses with next generation sequencing (IvySeq) to provide personalized enrollment recommendation.
  2. Pharmacodynamic analysis to assess treatment response and target modulation.
  3. Understanding resistance mechanisms of targeted inhibitors underlying disease progression.

Lab Members

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Siddhi Desai, PhDPostdoctoral Fellow

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Hualin Zhang, PhDPostdoctoral Fellow

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Anita DeSantisResearch Technician

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Jennifer MolloyResearch Technician

Resources

brainrnaseq.org

gliovis.bioinfo.cnio.es

portal.brain-map.org

antibodyregistry.org

biorxiv.org

clinicaltrials.gov

cancer.sanger.ac.uk/cosmic

JOB OPENINGS


Research Technician

The Ivy Brain Tumor Center is currently recruiting a highly motivated and driven research technician, (B.S. or M.S.) to join our PD team focusing on cutting edge Phase 0/II clinical trials for glioblastoma at BNI. Candidates with experience in preclinical studies are desirable. Prior experience in conducting drug treatment studies and knowledge of signal transduction pathways is preferred.