Tien Laboratory

Researcher holding a bottle of liquid in the lab

About

We actively pursue new drug combination clinical trials for brain tumor patients. The newly developed Phase 0 platform combined with precision medicine allows us to understand pharmacodynamic endpoints in the tumor, providing insights for overcoming the brain-blood barrier and drug target inhibition. The newly established Ivy Pharmacodynamics Core is CLIA-certified where our assays and biosamples are validated and carefully monitored to provide trustworthy clinical quality results. Our long-term goal is to understand cellular and molecular mechanisms underlying glioma formation, thereby speeding current drug discovery processes for glioma treatment in patients.

Current Research

Some of the ongoing projects are focused on addressing following:

  1. Biomarker and genomic analyses with next generation sequencing (IvySeq) to provide personalized enrollment recommendation.
  2. Pharmacodynamic analysis to assess treatment response and target modulation.
  3. Understanding resistance mechanisms of targeted inhibitors underlying disease progression.

Lab Members

Headshot of Siddhi Desai Read Bio

Siddhi Desai, PhDPostdoctoral Fellow

Hualin Zhang, PhD Read Bio

Hualin Zhang, PhDPostdoctoral Fellow

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Jordan FakhouryResearch Technician

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Tabassum HussainiResearch Technician

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Brian PhamResearch Technician

Resources

brainrnaseq.org

gliovis.bioinfo.cnio.es

portal.brain-map.org

antibodyregistry.org

biorxiv.org

clinicaltrials.gov

cancer.sanger.ac.uk/cosmic

JOB OPENINGS


Pharmacodynamics Research Technologist II

JOIN US NOW as we are seeking a RESEARCH TECHNICIAN to perform complex and novel procedures as a laboratory professional with a great degree of independence under the general supervision of a Principal Investigator (PI). Uses proven or develops as needed new scientific method(s) for new and routine experiments. Provides guidance to all personnel working in the laboratory. Maintains expertise on all matters concerning assigned laboratory personnel equipment and procedures.

This position is critical to the success of St. Josephs Hospital Medical Center and requires the full understanding and active participation in fulfilling the Mission of Dignity Health.