Tien Laboratory
About
We actively pursue new drug combination clinical trials for brain tumor patients. The newly developed Phase 0 platform combined with precision medicine allows us to understand pharmacodynamic endpoints in the tumor, providing insights for overcoming the brain-blood barrier and drug target inhibition. The newly established Ivy Pharmacodynamics Core is CLIA-certified where our assays and biosamples are validated and carefully monitored to provide trustworthy clinical quality results. Our long-term goal is to understand cellular and molecular mechanisms underlying glioma formation, thereby speeding current drug discovery processes for glioma treatment in patients.
Principal Investigator
Lab Members
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YuWei Chang, PhDPostdoctoral Fellow
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Chelsea Pennington-KrygierCLIA Lab Manager, Research Tech
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Anita DeSantisResearch Technician
Current and Published Research
- Tien et al., A Phase 0 Trial of Ribociclib in Recurrent Glioblastoma Patients Incorporating a Tumor Pharmacodynamic- and Pharmacokinetic-Guided Expansion Cohort. July 8, 2019.
- Griveau et al., A glial signature and Wnt7 signaling regulates glioma-vascular interactions and tumor microenvironment Cancer Cell April 19, 2018.
- Zhou et al., A sequentially priming phosphorylation cascade activates the gliomagenic transcription factor Olig2 Cell Reports April 18, 2017.
- Kupp et al., Lineage-restricted Olig2-RTK signaling governs the molecular subtype of glioma stem-like cells September 13, 2016.
- Tsai et al., Oligodendrocyte precursors migrate along vasculature in the developing nervous system. January 22, 2016.
- Yang et al., Rapamycin ameliorates age-dependent obesity associated with increased mTOR signaling in hypothalamic POMC neurons. August 9, 2012.
- Tien et al., Temporal-spatial regulation of astrocyte precursor cell proliferation by BRAF signaling in mammalian spinal cord. July 2012.
- Sun et al., Phosphorylation state of Olig2 regulates proliferation of neural progenitor. March 10, 2011.
JOB OPENINGS
Research Technician I
We are currently recruiting for a highly motivated and driven research technician, (B.S.) to join our CLIA-certified pharmacodynamics team focusing on cutting edge Phase 0 clinical trials for glioblastoma. Candidates with experience in preclinical studies are desirable. Prior experience in conducting histo-immunochemistry and knowledge of signal transduction pathways is preferred.