Mehta Laboratory

Researchers in lab

About

During brain development, cell fate factors play an important role in the coordinated regulation of neural stem cell proliferation and differentiation. The recent discovery of a small sub-population of ‘stem-like’ cells in brain tumors has shed light on the overlapping mechanisms between normal brain development and brain malignancies. There is a general consensus in the field that the brain tumors are maintained by the cancer stem cell population that has the capability to self-renew and differentiate into multiple cell types of the brain. The same neurodevelopmental cell fate factors have been shown to play critical roles in the formation and progression of brain tumors. Our laboratory studies the role of lineage-specific factors in brain tumor formation, progression, and therapy resistance. We are particularly interested in transcription factors that govern cell fate decisions during early brain development and their role in cancer progression and response to treatment.

CURRENT RESEARCH

Some of the ongoing projects are focused on addressing following questions:

  1. What genetic and epigenetic mechanisms are deregulated in cancer stem cells compared to normal neural stem/progenitor cells?
  2. Which neurodevelopmental pathways are hijacked by the cancer stem cells to promote therapy resistance?
  3. How can we exploit the interactions between cancer stem cells and the tumor microenvironment to specifically target brain tumor cells?

Ultimately, our goal is to provide a comprehensive understanding of the neurodevelopmental pathways hijacked by cancer stem cells and identify specific vulnerabilities to novel therapies.

Lab Members

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Costanza Lo Cascio, PhDPostdoctoral Fellow

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Sonam Patel, PhDPostdoctoral Fellow

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Anilkumar Thaghalli Shivanna, PhD

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James McNamaraResearch Technician

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Connor WhiteResearch Technician

Raymond HonRead Bio

Raymond HonResearch Technician

Zorana OpachichRead Bio

Zorana OpachichResearch Technician

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Leonel ElenaResearch Technician

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Mariya StavnichukResearch Technician

JOB OPENINGS


Research Technician I – Preclinical

The Ivy Brain Tumor Center is currently recruiting a highly motivated and driven research technician, (B.S. or M.S.) to join our animal modeling team focusing on cutting edge Phase 0/II clinical trials for glioblastoma at BNI. Candidates with experience in preclinical studies are desirable. Prior experience in conducting drug treatment studies and knowledge of signal transduction pathways is preferred.