Abstract Manuscripts

Last week, the Ivy Brain Tumor Center published a manuscript in Science Translational Medicine authored by Nader Sanai, MD, Shwetal Mehta, PHD, Artak Tovmasyan, PHD, An-Chi Tien, PHD, Igor Barani, MD, Charuta Furey, MD, and Zaman Mirzadeh, MD, in collaboration with other Ivy Center team members. The manuscript presents results from our early phase clinical trial utilizing sonodynamic therapy (SDT) in recurrent high-grade glioma patients. SDT pairs 5-aminolevulinic acid (5-ALA), which is metabolized to protoporphyrin IX in glioma cells, with noninvasive, image-guided focused ultrasound to trigger tumor-selective oxidative injury.

This week, the Ivy Brain Tumor Center published a manuscript in the Oxford University Press on behalf of the Society for NeuroOncology. The manuscript was authored by Nader Sanai, MD, Shwetal Mehta, PHD, and Roel G.W. Verhaak, PHD, in collaboration with other Ivy Center team members. The manuscript illustrates the results of our Phase 0/1 clinical trial combining two targeted drugs ribociclib (CDK4/6 inhibitor) and everolimus (mTOR inhibitor) in recurrent high-grade glioma patients, aiming to identify brain-penetrant combinations and assess their impact on malignant cell states.