High-Grade Glioma
Gliofocus – Phase 3 Study of Niraparib for Glioblastoma
The Gliofocus Study is a global, open-label, randomized Phase 3 clinical trial sponsored by the Ivy Brain Tumor Center that will compare the efficacy of niraparib, a PARP1/2-selective inhibitor, versus temozolomide in adult patients with newly diagnosed MGMT unmethylated glioblastoma.
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BDTX-1535 FOR RECURRENT HIGH-GRADE GLIOMA
The Ivy Brain Tumor Center is conducting a Phase 0/1 clinical trial to evaluate BDTX-1535, an experimental drug intended to block a key growth signal in patients with recurrent high-grade glioma, driven by EGFR (Epidermal Growth Factor Receptor) genetic aberrations.
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ONC201 IN NEWLY DIAGNOSED H3 K27M-MUTANT DIFFUSE GLIOMA
The Ivy Brain Tumor Center at Barrow Neurological Institute, a nonprofit translational research program, is conducting a Phase 3 study to evaluate ONC201 in patients with newly diagnosed H3 K27M-mutant diffuse glioma.
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Temsirolimus in Recurrent High-Grade Glioma
A Phase 0 dose-escalation study using superselective intra-arterial cerebral infusion of temsirolimus for the treatment of recurrent high-grade glioma.
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AZD1390 FOR GRADE 4 GLIOMA
A Phase 0/1b clinical trial to evaluate AZD1390 in patients with recurrent and newly diagnosed WHO grade 4 glioma.
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SONODYNAMIC THERAPY IN RECURRENT HIGH-GRADE GLIOMA
A Phase 0 research study of intravenous Aminolevulinic Acid Hydrochloride (ALA) and MR-guided focused ultrasound device (MRgFUS) in recurrent high-grade glioma patients.
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